Identification of a Receptor for Tumor Suppressor HIN-1
Annual summary rept. 15 Apr 2002-14 Apr 2003
DANA-FARBER CANCER INST BOSTON MA
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The goal of this project is to identify a receptor for the putative HIN-l tumor suppressor gene. HIN-l is a secreted protein therefore it is likely to exert its effect on cells through binding to a cell surface protein the HIN-1 receptor HIN-1R. Thus, in order to understand the function of HIN-l we have to identify and characterize the HIN-1 receptor. This year we have made significant progress towards understanding the function of HIN-1 and the signaling pathways it may be involved in. Although the molecular identity of the HIN-l receptor is still unknown, we have excluded several candidate receptors and signaling pathways and characterized the biochemical properties of the putative HIN-1 R in further detail. Since the previously described expression cloning approach has not led to the identification of a HIN-1 receptor, we are trying additional approaches described here.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research