Accession Number:

ADA416631

Title:

Identification of a Receptor for Tumor Suppressor HIN-1

Descriptive Note:

Annual summary rept. 15 Apr 2002-14 Apr 2003

Corporate Author:

DANA-FARBER CANCER INST BOSTON MA

Personal Author(s):

Report Date:

2003-05-01

Pagination or Media Count:

5.0

Abstract:

The goal of this project is to identify a receptor for the putative HIN-l tumor suppressor gene. HIN-l is a secreted protein therefore it is likely to exert its effect on cells through binding to a cell surface protein the HIN-1 receptor HIN-1R. Thus, in order to understand the function of HIN-l we have to identify and characterize the HIN-1 receptor. This year we have made significant progress towards understanding the function of HIN-1 and the signaling pathways it may be involved in. Although the molecular identity of the HIN-l receptor is still unknown, we have excluded several candidate receptors and signaling pathways and characterized the biochemical properties of the putative HIN-1 R in further detail. Since the previously described expression cloning approach has not led to the identification of a HIN-1 receptor, we are trying additional approaches described here.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE