Hepatocyte Growth Factor and Interleukin-6 in Prostate Cancer Bone Metastasis
Annual rept. 15 Feb 2002-14 Feb 2003
CORNELL UNIV MEDICAL COLL NEW YORK
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Overview of tasks accomplished in the first year. In the first year of the award, we evaluated the design and progression of experiments of the project. We completed the first task, listed in the statement of work. In addition, I moved from Cornell University to the Fred Hutchinson Cancer Research Center. The environment at FHCRC is conducive to abroad genome wide analysis to determine the entire spectrum of androgen-regulated growth factors in bone, which is listed under task 4. As a first step, we analyzed the expression of hepatocyte growth factor HGF and interleukin-6 IL-6 in mouse bone, which is part of task 1. We also evaluated changes in expression levels as a result of androgen deprivation of bone and bone marrow. The assay development and results are listed in detail in the following section.
- Anatomy and Physiology
- Medicine and Medical Research