Role of Chromatin Remodeling by RAD54 in DNA Damage Repair and Homologous Recombination
MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER
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Chromosomal double-strand breaks DSBs can arise from cellular DNA metabolism and from eogenous DNA-damaging agents. Efficient repair of these DSBs is critical for genome stability. Rad54, a member of the SWI2SNF2 family, is involved in the homology recombination ER DNA repair pathway. Rad54 has been shown to physically associate with Rad51, a eukaryotic recombinase that in mammals interacts with tumor suppressors BRCA1 and BRCA2.
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