Accession Number:

ADA416619

Title:

Role of Chromatin Remodeling by RAD54 in DNA Damage Repair and Homologous Recombination

Descriptive Note:

Annual summary

Corporate Author:

MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER

Personal Author(s):

Report Date:

2003-04-01

Pagination or Media Count:

19.0

Abstract:

Chromosomal double-strand breaks DSBs can arise from cellular DNA metabolism and from eogenous DNA-damaging agents. Efficient repair of these DSBs is critical for genome stability. Rad54, a member of the SWI2SNF2 family, is involved in the homology recombination ER DNA repair pathway. Rad54 has been shown to physically associate with Rad51, a eukaryotic recombinase that in mammals interacts with tumor suppressors BRCA1 and BRCA2.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE