Investigation of Novel Human CED-4 Homolog NAC-X in Apoptosis Regulation of Breast Cancer
Annual summary rept. 1 May 2002-30 Apr 2003
BURNHAM INST LA JOLLA CA
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Proteins containing a Caspase-Associated Recruitment Domain CARD have previously been shown to serve as key regulators of tumor cell survival as well as regulators of other cellular processes, such as cytokine production. Interleukin-1 beta IL-1Beta is a pro-inflammatory cytokine which has been found to be associated with more aggressive and invasive breast tumors. Previous work year 1 focused on the initial cloning and functional characterization of NAC-X now named CLAN, a novel protein containing CARD, NACHT and LRR domains. NAC-X was previously found to regulate caspase-1 and IL-1Beta activation, more recent experiments have determined that NAC-X may also affect the functions of other NACHT-containing proteins via heterotypic associations through its NACHT domain. Furthermore, NAC-X was found to elicit an inflammatory response in macrophages following exposure to the bacterial component LPS, suggesting a role for this gene in the innate immune system. It remains to be determined whether NAC-X-mediated IL-1Beta secretion may function as a growth or survival factor in breast tumors.
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