Diagnostic Systems for Pulsed Electric Field Studies
Final rept. 1 Jan 2002-30 Apr 2003
OLD DOMINION UNIV NORFOLK VA
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Experimental and modeling studies have shown that nanosecond electric fields allow us to affect internal structures of biological cells. Electrical diagnostics work with temporal resolution in the sub-nanosecond range is critical for evaluation of such ultrafast pulses for the extension of this new bioelectric technique from presently used electrode application in cell suspensions and tissues, to electromagnetic field interactions using antennas. Experiments are ongoing using the 4 GHz bandwidth oscilloscope purchased by this grant for studies on pulsed electron heating in plasmas and electrical breakdown of liquids. Another purchase in support of bioelectrics research is a Time Domain Dielectric Spectroscopy TDDS system. It allows us to measure the complex dielectric constant of biological suspensions, and via modeling, get information on cell membrane resistivities and capacitances. A TDDS-system, developed specifically for biological studies, has been purchased from IDC Expertise LDC, and has recently generated the first results on the temporal development of the electrical parameters of HL6O cells in pulsed electric fields.
- Medicine and Medical Research
- Lasers and Masers
- Electricity and Magnetism