Biological Differences Between Prostate Cancer Cells That Metastasize to Bone Versus Soft Tissue Sites
Annual rept. 19 Nov 2001-18 Nov 2002
MICHIGAN UNIV ANN ARBOR
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Nearly 100 of men who die of prostate cancer suffer from painful bone metastases. A major question in prostate cancer biology is why prostate cancer preferentially metastasizes to bone. A better understanding of how PC metastasizes to bone is the first step in defining a therapeutic strategy to block the development of these metastases. In this last period, we have Task 1 Investigated how the bone microenvironment modulates growth and adhesion of VCaP versus DuCaP by investigating the effects of known bone marrow cytokines- and bone ECM on the growth of VCaP and DuCaP. Task 2 We have begun to investigate the differential gene expression of VCap versus DuCaP cells by cDNA microarrays to identify specific gene products important in the metastasis of prostate cancer to bone by gene profiling.
- Anatomy and Physiology
- Medicine and Medical Research