A Novel High-Resolution Positron Emission Tomography System for Measurement of Bone Metabolism
Annual rept. 1 Sep 2001-31 Aug 2003
MASSACHUSETTS GENERAL HOSPITAL BOSTON
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The purpose of the work reported here is to develop high-resolution PET instrumentation for imaging the long bones. To-date a single plane prototype and a single plane second-generation instrumentation have been completed. The latter is currently being evaluated. A generalized multi-planar detector element has also been designed and evaluated experimentally and a volumetric instrument has been designed through simulation studies. A radiopharmaceutical for bone growth rate imaging, labeled C-tetracycline 11 has been developed for use in a demonstration study of imaging in a monkey osteoporosis model.
- Medicine and Medical Research