PCBs Alter Dopamine Mediated Function in Aging Workers
Annual rept. 15 Dec 2001-14 Dec 2002
HEALTH RESEARCH INC RENSSELAER NY
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The major hypothesis is that occupational exposure to polychiorinated biphenyls PCBs results in decrements in neuropsychological and neurological performance and the number of dopamine DA terminals in the basal ganglia of former capacitor workers. 248 subjects will undergo neuropsychological and neurological examinations, complete a comprehensive questionnaire, have blood drawn to measure serum PCB concentrations and undergo a non-invasive test to determine bone lead concentrations in Albany, New York. Approximately 40 of the subjects chosen randomly will be asked to undergo brain imaging at the Institute for Neurodegenerative Disorders in New Haven, CT to determine if PCBs reduce the number of basal ganglia DA terminals IRB approvals have been obtained from all institutions the X-ray fluoresence system for bone lead measurement has been assembled and calibrated interview questionnaires have been piloted a nursestudy coordinator has been hired and trained by staff epidemiologists and we have begun tracing, recruiting and testing subjects. To date twelve subjects are eligible based on minimum age, distance of primary residence from Albany and the absence of certain medical conditions. Only three of them have refused to participate. Our goal is to schedule eight subjects per month until all 248 subjects have been tested.
- Medicine and Medical Research