Accession Number:

ADA415983

Title:

Proteolytic Mechanisms of Cell Death Following Traumatic Brain Injury

Descriptive Note:

Annual rept. 1 Oct 2000-30 Sep 2001

Corporate Author:

FLORIDA UNIV GAINESVILLE

Personal Author(s):

Report Date:

2001-10-01

Pagination or Media Count:

29.0

Abstract:

The research within the second year has provided novel and important information indicating that calpain activation can be detected following TBI in the cerebrospinal fluid of injured animals. These data have important implications for clinical and laboratory studies of pathophysiological responses to TBI. It is possible that similar techniques can be used in humans to assess the presence of destructive proteases following TBI If such is the case, this could lay the ground work for important and novel biochemical markers of injury following human TBI. More importantly, such markers would provide information not only in the magnitude of injury but the mechanisms underlying such injury. Next, our studies have indicated that caspase-3 activity may play a more important role in experimental TBI than we had originally speculated. Equally important, our data suggests that regulation of caspase-3 activity may be via a precursor caspase, caspase-8. The knowledge of the regulation of caspase-3 activity following TBI could provide important insights into therapeutic opportunities to treat TBI

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE