Neuroprotective Ganglioside Derivatives
Annual rept. 15 Aug 2001-14 Aug 2002
MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER
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In this study, neuroprotective ganglioside derivatives are examined so they can be targeted to specific points in cell death pathways. GM1 ganglioside and several of its chemically modified derivatives are neuroprotective in several neurotoxic models. Here, ganglioside functional groups required for neuroprotection and blood-brain barrier BBB permeance are determined Cell death mechanisms are also defined, as are the mechanisms by which ganglioside derivatives intervene in the cell death process. In the first year, substantial quantities of GM1 have been isolated and purified.
- Medicine and Medical Research