Accession Number:

ADA415963

Title:

Neuroprotective Ganglioside Derivatives

Descriptive Note:

Annual rept. 15 Aug 2001-14 Aug 2002

Corporate Author:

MASSACHUSETTS UNIV MEDICAL SCHOOL WORCESTER

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

21.0

Abstract:

In this study, neuroprotective ganglioside derivatives are examined so they can be targeted to specific points in cell death pathways. GM1 ganglioside and several of its chemically modified derivatives are neuroprotective in several neurotoxic models. Here, ganglioside functional groups required for neuroprotection and blood-brain barrier BBB permeance are determined Cell death mechanisms are also defined, as are the mechanisms by which ganglioside derivatives intervene in the cell death process. In the first year, substantial quantities of GM1 have been isolated and purified.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE