Role of Map Kinase in Mediating the Effects of Vitamin D3 Metabolites on Growth Plate Chondrocytes
TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO
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Endochondral bone formation involves a developmental cascade of cell differentiation and maturation, which culminates in mineralization of the extracellular matrix by chondrocytes. The process is required for normal long bone growth and in certain kinds of bone repair. Vitamin D3 plays an important regulatory role in chondrocyte differentiation and maturation and therefore is essential for proper endochondral ossification. The vitamin D3 family contains two metabolites, 1alpha,25OH2D3 and 24R,25OH2D3, which have been shown to be active in growth plate cartilage. The actions of these vitamin D3 metabolites are cell maturation-dependent, with lalpha,25OH2D3 primarily affecting growth zone chondrocytes and 24R,25OH2D3 primarily affecting resting zone chondrocytes. Regulation of endochondral bone formation involves both of these vitamin D3 metabolites.
- Medicine and Medical Research