Accession Number:

ADA415870

Title:

Alpha Synuclein Aggregation in a Neurotoxic Model of Parkinson's Disease

Descriptive Note:

Annual rept. 1 Aug 2001-31 Jul 2002

Corporate Author:

BOSTON UNIV MA SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2002-08-01

Pagination or Media Count:

29.0

Abstract:

The neurotoxin 1-methyl-4-phenyl-tetrahydropyridine MPTP inhibits mitochondrial oxidative phosphorylation and replicates the pattern of neuronal neurodegeneration in Parkinsons disease PD. Neurons that degenerate in PD develop inclusions containing aggregates of a synaptic protein, alpha synuclein. The purpose of this study is to determine how MPTP and other neurotoxins affect cytoskeletal and synaptic proteins and to study the relationship between oxidative damage and synuclein aggregation.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE