Accession Number:

ADA415864

Title:

The Role of Focal Adhesion Kinase and CAS in Integrin-Mediated Signaling on Distinct Forms of Laminin-5

Descriptive Note:

Annual summary rept. 1 Jul 2001-30 Jun 2002

Corporate Author:

BIOFORCE NANOSCIENCE INC AMES IA

Personal Author(s):

Report Date:

2002-07-01

Pagination or Media Count:

15.0

Abstract:

This report details final work on this project that was performed while the principal investigator was at University of Nevada Las Vegas. This project has currently been re-defined and the work is being performed at BioForce Nanosciences, Inc. Ames IOWA. The goals of this project were to define signaling pathways triggered in immortalized breast epithelial cells MCF10A when these cells bind to and migrate on distinct forms of laminin-5. Activation of FAK and MAPK kinase were shown to occur upon engagement of non- migratory forms of laminin-5 only in the presence of the Beta 1 integrin activating antibody Ts216.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE