Accession Number:

ADA415833

Title:

Analysis of Human AXIN2 and Other Wnt Signal Pathway Genes in Human Prostate Cancer

Descriptive Note:

Annual summary rept. 1 Mar 2002-28 Feb 2003

Corporate Author:

MAYO CLINIC ROCHESTER MN

Personal Author(s):

Report Date:

2003-03-01

Pagination or Media Count:

12.0

Abstract:

Upregulation of cyclin D1, a key regulator of cell cycle, by elevated beta-catenin through the disruption of Wnt signaling pathway is often seen in colon cancer and breast cancer. Cyclin D1 overexpression is also reported in about 25 of human prostate cancer where only about 5 mutation in beta catenin is found. Human AXIN2 and other components in the Wnt signaling pathway may also contribute to cyclin D1 elevation.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE