A Novel Apoptotic Molecular Bok for the Treatment of Breast Cancer
Annual summary rept. 1 Mar 2002-28 Feb 2003
M D ANDERSON CANCER CENTER HOUSTON TX
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This current proposal is based on previous publications that 1 the proapoptotic Bcl-2 family member Bok, is capable of exerting growth inhibition on cancer cells growing in tissue culture, and 2 the apoptotic activity of Bok is not inhibited by the anti- apoptotic molecules Bcl-2 and BclxL. To further investigate the anti-tumor activity of Bok on breast cancer and to develop a Bok gene therapy for breast cancer, we have proposed three specific aims to accomplish our objectives. Specific Aim 1 To confirm hBok-mediated transformation suppression in breast cancer cells. Specific Aim 2 To investigate the mechanisms of hBok-induced apoptosis. Specific Aim 3 To develop a tumor specific promoter using hTERT promoter driven hBok to examine the preclinical effect of hBok for breast cancer gene therapy.
- Anatomy and Physiology
- Medicine and Medical Research