The Role of Beta-Catenin in Mammary Gland Development and Breast Cancer
Annual summary rept. 1 Mar 2000-28 Feb 2003
BAYLOR COLL OF MEDICINE HOUSTON TX
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Many of the molecular events that control normal development of the mammary gland are the same events that, when misregulated, result in cancer. Therefore, the understanding of normal developmental processes in the mammary gland is a crucial first step to rational design of therapeutics which target these systems in breast cancer. The Wnt family of genes, which were first identified for their role in mouse mammary tumorigenesis, initiate a signaling cascade that manifests in the stabilization of beta-catenin protein. The proposed experiments are based on the hypothesis that misregulation of this pathway results in an accumulation of stabilized beta-catenin, and genes involved in growth, cell death, and cell invasion are upregulated inappropriately, resulting in tumorigenesis.
- Anatomy and Physiology
- Medicine and Medical Research