Accession Number:

ADA415721

Title:

Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis

Descriptive Note:

Final rept. 15 Feb 2000-14 Feb 2003

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

Report Date:

2003-03-01

Pagination or Media Count:

218.0

Abstract:

We have been developing conditionally replicative adenoviral agents CRADs for prostate cancer gene therapy. We have sought to improve these agents by increasing their infectivity for tumor targets and by enhancing the specificity of their replication exclusively within tumor targets.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE