Infectivity-Enhanced Adenoviruses for Improved Replicative Oncolysis
Final rept. 15 Feb 2000-14 Feb 2003
ALABAMA UNIV IN BIRMINGHAM
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We have been developing conditionally replicative adenoviral agents CRADs for prostate cancer gene therapy. We have sought to improve these agents by increasing their infectivity for tumor targets and by enhancing the specificity of their replication exclusively within tumor targets.
- Medicine and Medical Research