A Quantitative MRI Study of Prostate Cancer Before and After Radiation Therapy
Annual rept. 15 Apr 2002-14 Apr 2003
MANCHESTER UNIV (UNITED KINGDOM)
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The purpose of the study is to examine the influence of external beam radiation on the prostate and prostate cancer using novel quantitative MRI techniques. Twenty-one men, previously diagnosed with prostate cancer, will be studied using T2 relaxation mapping and contrast agent kinetic methods before and after treatment by radiotherapy. The MRI findings will be correlated with biochemical prostate specific antigen progression and biopsy results. At the end of year 3 all 21 patients have been recruited and studied pre-treatment. Two patients have returned for follow-up MRI. The data is both complete and of a high quality. Preliminary data analysis has provided important and novel information about the microvascular characteristics of prostate cancer. These results are shortly to be presented at a leading international scientific conference and will form the basis of a manuscript currently in preparation. Furthermore, these studies have generated a parallel line of novel research the estimation of arterial input functions using MRI.
- Medicine and Medical Research