Accession Number:

ADA415706

Title:

Dietary Genistein and Prostate Cancer Chemoprevention

Descriptive Note:

Annual rept. 1 Apr 2002-31 Mar 2003

Corporate Author:

ALABAMA UNIV IN BIRMINGHAM

Personal Author(s):

Report Date:

2003-04-01

Pagination or Media Count:

7.0

Abstract:

The disease of cancer is usually attacked at time of diagnosis, and even chemoprevention is not usually considered until adulthood. Our hypothesis is that windows of development hold the key for chemoprevention of prostate cancer. We have previously demonstrated that genistein is bioavailable to the rat prostate and that life-time exposure to physiological concentrations of genistein suppressed the development of chemically-induced prostate cancer. The purpose of our research is to determine if there is a developmental window for this chemoprevention and the mechanism s of chemoprevention. The importance of this lies in the need to know, prior to initiation of human trials, if we need to expose infants andor adults to get maximum chemoprevention. We have proposed to accomplish this in a dietary model at physiological concentrations. To date, we have demonstrated that neonatal and prepubertal exposure to genistein via the diet does not alter development of the prostate buds in 21 and 35 day old rats. Chemoprevention experiments are in progress to determine the critical period of exposure for protection against chemically-induced prostate cancer in rats.

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE