Accession Number:

ADA415692

Title:

Role of CDC25A in Breast Cancer Development

Descriptive Note:

Annual rept. 15 Mar 2002-14 Mar 2003

Corporate Author:

ILLINOIS UNIV AT CHICAGO

Personal Author(s):

Report Date:

2003-04-01

Pagination or Media Count:

9.0

Abstract:

A recent study showed that about 50 of small breast cancers have higher expression of CDC25A protein than normal breast tissues, suggesting that CDC25A overexpression plays an important role in development of breast cancer. The long-term goal of this proposed program is to understand how CDC25A participates in cellular transformation to cancer. The objective of this application is to determine whether the expression level of CDC25A is rate-limiting for development of breast cancer. Our working hypothesis is that CDC25A plays dual functions of promoting cell divisions and suppressing cell death by activating cyclin-dependent kinases and inhibiting apoptosis signal-regulating kinase-I ASKI, respectively. This proposed study is innovative because the interaction of CDC25A and ASK-1 is our novel discovery, and it is a good candidate for coordinated control of cell division and death during cancer development, according to the known functions of these two proteins. It is directly related to the biology of breast cancer, addressing a mechanism of breast cancer development. The study will also generate novel mouse models for breast cancer, which could be used for future studies to develop cancer therapies. We expect that this program will provide significant insight into the mechanism of breast cancer development.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE