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Locating a Prostate Cancer Susceptibility Gene on the X Chromosome by Linkage Disequilibrium Mapping Using Three Founder Populations in Quebec and Switzerland

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Annual rept. 1 Mar 2002-28 Feb 2003

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The funded proposal has not yet begun at all sites. We have yet to receive the SPA for the Chicoutimi site but we are confident that this will happen shortly as all the necessary documents have been sent for final review by the Army. Due to the delay with ethics approval, we applied and received a no cost extension for this proposal. At the Montreal site, 153 participants have consented to participate and their blood was drawn. We have another 20 men that have agreed to participate and their blood will be drawn in the next few months. We are continuing to ascertain new cases as via hospitals tumor registries. We have recruited a total of 29 controls. The pedigrees for all controls and cases have been drawn. Ishihara charts were shown to all cases and controls and the results were recorded. At the Switzerland site, case ascertainment is underway. To date, four physician have given their support to this project and we anticipate the participation of more physicians. The cancer registry in Bern has been contacted to request a patient list and a favorable decision is expected in March or April 2003. Seven patients have been contacted so far and S patients consented and gave blood. Repeated contacts have lead us to believe we can expect many more over the next few months. We have published work in the Journal of Medical Genetics for the testing of RNASEL47delAAAG on our cases.

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  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

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