The Role of BetaII Isotype of Tubulin in Diagnosis and Development of Prostate Cancer
Annual rept. 1 Jan-31 Dec 2002
TEXAS UNIV HEALTH SCIENCE CENTER AT SANANTONIO
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We have previously found that the Betasub II isotype of tubulin occurs in the cell nuclei of a large number of prostate cancers. In this project, we have examined prostate cancers from two groups of prostatectomies, one set originating with patients whose cancer recurred and the other from a mixture of patients. We found that Betasub II was expressed in a substantial fraction of prostate tumors in both sets of patients. We also observed that, for the subclass that expressed Betasub II, the Betasub II occurred more frequently in the nuclei and much less frequently in the cytoplasm alone in the set of patients whose cancer is likely to recur. We also examined the distribution of two other isotypes of tubulin, Betasub I and Betasub III, in prostate and other cancers. We found that Betasub I was common in all cancers, Betasub III was less common in prostate cancer and that nuclear occurrence of these isotypes was very infrequent in any cancer. Our results suggest that nuclear Betasub II is a promising predictive biomarker for recurrence of prostate cancer while Betasub I and Beta sub III are not likely to become good biomarkers.
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