Accession Number:

ADA415553

Title:

Hereditary Breast Cancer: Mutations Within BRCA1 and BRCA2 with Phenotypic Responses

Descriptive Note:

Final addendum rept. 1 Jul 1997-30 Jun 2002

Corporate Author:

CREIGHTON UNIV OMAHA NE

Personal Author(s):

Report Date:

2002-07-01

Pagination or Media Count:

29.0

Abstract:

From 85 hereditary breast cancer families, 285 invasive breast carcinomas from patients with known BRCA12 mutations were analyzed for histo-pathological features, c-erbB2, estrogen receptor ER and progesterone receptor PR expression This study confirms previous data showing that BRCA1 HBC displays an aggressive biological phenotype characterized by high S-phase fraction and low estrogen and progesterone receptor expression suggesting that BRCA1 breast cancer generally will not respond well to therapy with hormone receptor modulators such as tamoxifen.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE