Hereditary Breast Cancer: Mutations Within BRCA1 and BRCA2 with Phenotypic Responses
Final addendum rept. 1 Jul 1997-30 Jun 2002
CREIGHTON UNIV OMAHA NE
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From 85 hereditary breast cancer families, 285 invasive breast carcinomas from patients with known BRCA12 mutations were analyzed for histo-pathological features, c-erbB2, estrogen receptor ER and progesterone receptor PR expression This study confirms previous data showing that BRCA1 HBC displays an aggressive biological phenotype characterized by high S-phase fraction and low estrogen and progesterone receptor expression suggesting that BRCA1 breast cancer generally will not respond well to therapy with hormone receptor modulators such as tamoxifen.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research