Accession Number:

ADA415521

Title:

Role of a Novel Prostate-Specific G-Protein Coupled Receptor (PSGR) in Prostate Tumor Development

Descriptive Note:

Annual rept. 15 Jan 2002-15 Jan 2003

Corporate Author:

TEXAS A AND M RESEARCH FOUNDATION COLLEGE STATION

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

63.0

Abstract:

G-protein coupled receptors GPCRs receive many of the neural, hormonal, and paracrine inputs to activate different types of cells, regulating intracellular second messengers and a variety of cellular functions, including cell growth and proliferation. Constitutive activation of a number of G-protein coupled receptors have been linked to the proliferative signaling pathways and a number of human neoplasias. Most recently, we have identified a novel prostate-specific G-protein coupled receptor PSGR. Northern blot analysis indicates that the expression of PSGR is increased significantly in human prostate cancers compared to normal prostate tissues, suggesting a potential role of PSGR in prostate tumor progression and development.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE