Permanent Implantation Brachytherapy for Prostate Cancer Using a Mixture of Radionuclides with Different Half Lives
Annual rept. 1 Mar 2002-28 Feb 2003
YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE
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The objective of the project is to test whether the therapeutic effectiveness of permanent implant brachytherapy for prostate cancer can be improved by using a combination of short and long half life radionuclides simultaneously. A theoretical model for continuous low dose rate irradiation using a mixture of radionuclides has been developed. Experiments have been performed using BA1112 tumor cells and Chinese Hamster cells growing in vitro and BA1112 cells growing in vivo as solid tumors in WAGrij rats. Radiobiology parameters for these cells have been determined and used in the theoretical radiobiology model to improve our understanding of the experimental observations. We have designed and fabricated applicators for in vivo irradiations as well as developed the animal care procedures.
- Medicine and Medical Research