Accession Number:

ADA415338

Title:

Interaction Between a Novel p21 Activated Kinase (PAK6) and Androgen Receptor in Prostate Cancer

Descriptive Note:

Annual rept. 1 Feb 2002-31 Jan 2003

Corporate Author:

STANFORD UNIV MEDICAL CENTER CA

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

24.0

Abstract:

The androgen-signaling pathway is important for the growth and progression of prostate cancer. The cell cycle signaling regulated by mitogen activated proteinextracellular-signal-regulated kinase MAPKIERK have been linked to tumorigenesis. The p2l-activated kinases PAKs are members of a growing class of RacCdc42-associated Ste20-like serthr protein kinases. Recent studies have shown that MAPKERK signaling can be mediated via Cdc42Rac-stimulation of PAK activity. Recently, we demonstrated a specific interaction between a novel PAK protein, PAK6, and AR. This finding provided the first link between PAK-mediated signaling to the steroid hormone receptor pathway. In this study, we propose to assess the biological roles of PAK6 in prostate cancer cells, and to examine the expression of PAK6 in prostate tissues. We anticipate that by completing the objectives proposed in this grant, we will obtain fresh insight into the regulatory processes of AR and PAK6 that may be targeted for the development of a drug in the treatment of prostate cancer.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE