Accession Number:

ADA415331

Title:

Corrective 111In Capromab Pendetide SPECT Image Reconstruction Methods for Improved Detection of Recurrent Prostate Cancer

Descriptive Note:

Annual rept. 1 Feb 2002-31 Jan 2003

Corporate Author:

NORTH CAROLINA UNIV AT CHAPEL HILL

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

13.0

Abstract:

It is generally recognized that 111In capromab pendetide PS scans are technically challenging to perform and interpret, particularly with regard to pelvic SPECT studies used to detect possible disease in the prostate fossa and pelvic lymph node LN. The hypothesis of this proposal is that the superior spatial resolution, high image contrast, and much reduced image artifacts that result from the corrective SPECT image reconstruction methods would substantially aid in the detection and diagnosis of prostate cancer. To test our hypothesis, we propose five specific aims 1 to develop simulation tools and methods that allow efficient generation of accurate 111In PS projection data from the human pelvic area, 2 to study the effects of 3D image degrading factors on 111In PS SPECT images, 3 to develop 3D corrective image reconstruction methods for 111In PS SPECT that provide much improved image quality and quantitative accuracy by incorporating models of the 3D image degrading factors, 4 to evaluate the 3D corrective image reconstruction methods for clinical 111In PS SPECT studies using simulated patient data, and Hotelling and human observer studies, and 5 to evaluate the clinical efficacy of the corrective image reconstruction methods as applied to 111In PS SPECT using patient data.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE