Accession Number:

ADA415319

Title:

Role of Bin1 in Cellular Senescence and Apoptosis by E2F1 in Androgen-Independent Prostate Cancer Cells

Descriptive Note:

Annual rept. 1 Feb 2002-31 Jan 2003

Corporate Author:

PURDUE UNIV LAFAYETTE IN

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

15.0

Abstract:

Cancer is a disease of aberrant cell growth. The c-Myc oncogene is commonly activated in tumors, including prostate cancers, and its over expression has been linked to both cell cycle progression and the induction of apoptosis however the ambiguous role of this transcription factor has yet to be elucidated. The c-Myc function lies between two signaling networks that target its C-terminal DNA binding domain as well as its N-termini transcriptional activation domain. Bin1 Bridge integrator-1 is a Myc-interacting protein that associates with the N-terminus of the Myc oncoprotein and inhibits malignant transformation induced by c-Myc and adenovirus E1A. However, deletion mutants of Bin1 lacking the Myc-binding domain MBD were still capable of inhibiting cellular transformation of oncogenic Ras mediated by adenovirus ElA, thus indicating that Bini can inhibit malignant cell growth in a Myc-independent manner.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE