Accession Number:

ADA415253

Title:

Synthesis of Lipoprotein Immunostimulants for Treating Prostate Cancer

Descriptive Note:

Annual rept. 1 Jan 2002-31 Dec 2002

Corporate Author:

UTAH UNIV SALT LAKE CITY

Personal Author(s):

Report Date:

2003-01-01

Pagination or Media Count:

13.0

Abstract:

The prospects of stimulating a patients own immune system as a therapeutic approach to the treatment of cancer in general and prostate cancer in particular is intriguing However thus far immunotherapeutic approaches to the treatment of cancer including prostate cancer in the clinical setting have not been uniformly successful We are chemically synthesizing molecular conjugates that comprise a Toll-Like Receptor TLR ligand covalently linked to a prostate cancer tumor-associated antigen protein or peptide Using this tactic we anticipate that the TLR-ligand portion of the conjugates will stimulate dendritic cells DOs as well as other TLR-expressing antigen presenting cells in vivo through TLR signaling pathways to secrete immune-activating cytokines while the tumor antigen component of the complex will be processed and presented to activated T cells In this way, a new and potent immune system stimulation and antigen presentation mechanism aimed at the stimulation of combined GD8 and CD4 T-cell responses, along with B-cell activation via the innateadaptive immune response connection, is being developed We have prepared TLR-4 and TLR-7 ligands and are preparing mouse immunization experiments to test the efficacy of this new approach to cancer immunotherapy.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE