Accession Number:

ADA415018

Title:

High Throughout Synthesis and Screening for Agents Inhibiting Androgen Receptor Mediated Gene Transcription

Descriptive Note:

Annual rept. 1 Feb 2002-31 Jan 2003

Corporate Author:

SCRIPPS RESEARCH INST LA JOLLA CA

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

10.0

Abstract:

Details of the year 1 progress on our grant to define a new treatment of therapeutic resistant prostate cancer is provided. This entails the high throughput synthesis of DNA binding agents related to distamycin, their screening for binding to androgen response elements using a new high throughput DNA binding screen we introduced, and the evaluation for inhibiting androgen receptor mediated gene transcription and the cell proliferation of a prostate cancer cell line

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE