Accession Number:

ADA415000

Title:

Genetic Susceptibility to Prostate Cancer Among Ashkenazi Jews

Descriptive Note:

Annual rept. 15 Sep 2001-14 Sep 2002

Corporate Author:

NEW YORK UNIV MEDICAL CENTER NY

Personal Author(s):

Report Date:

2002-12-01

Pagination or Media Count:

6.0

Abstract:

This project will test the basic hypothesis that a given microsatellite marker allele occurs with greater frequency among the individuals affected with prostate cancer than among the controls. These studies will take advantage of the fact that two populations of Ashkenazi Jewish men are readily available for a case- control study. The first is a group of men at high heritable risk based on their having early-onset prostate cancer. The second is a group of men at low heritable risk who have no personal or family history of prostate cancer. Thus, we expect to observe predisposition alleles in the men at high risk that are not present in the men at low risk. The predisposition genes are likely to be within chromosomal regions in which loss of heterozygosity has occurred. Because these regions have remained identical by descent since the high-risk mutations occurred, they can be recognized by the presence of specific alleles of microsatellite markers in the high-risk group that are not present in the low-risk group.

Subject Categories:

  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research
  • Humanities and History

Distribution Statement:

APPROVED FOR PUBLIC RELEASE