HRAD51 Involvement in Genomic Instability and Development of Breast Cancer
Annual rept. 23 Aug 2001-22 Aug 2002
THOMAS JEFFERSON UNIV PHILADELPHIA PA
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During the third year of the funded period, we focused on the characterization of interactions between hRAD51 and the five hRAD51 paralogs. We detected strong interactions suggesting a stable complex, and weaker interactions Some of these weaker interaction signals between hRAD51 paralogs increased in the presence of ATP and decreased in the presence of ADP which may indicate a regulatory role for adenosine nucleotides We also continued in our effort to purify the paralogs and heterodimers thereof. Examination of the functional significance of these interactions and the role of adenosine nucleotides is currently in progress.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research