Developing and Understanding Methods for Large Scale Nonlinear Optimization
Final rept. 16 Mar 1998-31 Dec 2001
COLORADO UNIV AT BOULDER
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Our main activity in this grant has been the development and testing of techniques for solving global optimization problems for determining the structure of proteins and polymers. The problem is to find the lowest energy configuration of a protein or other polymer. This problem is a global optimization problem because it has a huge number of local minimizers. In addition, locating the lowest global minimizer is very difficult. For proteins, the solution of this problem would represent a solution to the well known protein-folding problem.
- Operations Research
- Atomic and Molecular Physics and Spectroscopy