Accession Number:

ADA413879

Title:

Oxidized DNA Bases in Breast Cancer

Descriptive Note:

Annual summary 1 Aug 1999-31 Jul 2002

Corporate Author:

NEW YORK UNIV NY SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2002-08-01

Pagination or Media Count:

9.0

Abstract:

Recently more studies have correlated the elevated 5-hydroxymethyl-2-deoxyuridine HMdU - an oxidized DNA base levels with an increased risk of cancer when compared to controls. HMdU has been proposed to be a biomarker for breast cancer risk Although methods are available, but requires larger sample sizes between 50- 100 micrograms DNA, which limits its application for HMdU quantitation in relatively smaller sample size We have developed a sensitive method to detect and quantitate HMdU using fluorescent coumarin derivative to label HMdU and other nucleosides.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE