Accession Number:

ADA413858

Title:

X-Ray Crystallography of Botulinum Neurotoxin Type E and Its Functional Subunits

Descriptive Note:

Final rept. 15 Nov 1997-31 Dec 2002

Corporate Author:

DEPARTMENT OF VETERANS AFFAIRS PITTSBURGH PA

Report Date:

2002-12-01

Pagination or Media Count:

12.0

Abstract:

Botulinum Neurotoxin type E was crystallized and an electron density map was analyzed at 3 alpha resolution. A new crystal form was also obtained, and may be helpful in improving the phasing. Co-crystallization experiments with gangliosides have also been undertaken. The structure of a complex between tetanus toxin C-fragment and doxorubicin has been determined, and drug binding occurs at the ganglioside binding site. Structure determination of a complex between tetanus toxin C fragment and the ganglioside GDlb is underway, and data have been collected.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE