Characterization of Two C. Elegans Homologuses of Oncogenic Inhibitor of Apoptosis Proteins (IAPs) and Identification of Interacting Genes
Annual summary rept. 1 Aug 1999-1 Aug 2002
CAMBRIDGE UNIV (UNITED KINGDOM)
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The C. elegans gene bir-1 was identified as being a homologue of the Inhibitor of Apoptosis Proteins IAPs. These are known regulators of apoptosis in both insects and mammals. I showed in my previous lab that rather than playing a role in regulating the well-characterized apoptotic machinery in C. elegans, bir-1 instead plays an essential role in cytokinesis. Furthermore this role appears to be evolutionarily conserved as a mammalian homologue of bir-1 could functionally complement bir-1 in C. elegans.
- Medicine and Medical Research