Accession Number:

ADA413751

Title:

Characterization of Two C. Elegans Homologuses of Oncogenic Inhibitor of Apoptosis Proteins (IAPs) and Identification of Interacting Genes

Descriptive Note:

Annual summary rept. 1 Aug 1999-1 Aug 2002

Corporate Author:

CAMBRIDGE UNIV (UNITED KINGDOM)

Personal Author(s):

Report Date:

2002-09-01

Pagination or Media Count:

12.0

Abstract:

The C. elegans gene bir-1 was identified as being a homologue of the Inhibitor of Apoptosis Proteins IAPs. These are known regulators of apoptosis in both insects and mammals. I showed in my previous lab that rather than playing a role in regulating the well-characterized apoptotic machinery in C. elegans, bir-1 instead plays an essential role in cytokinesis. Furthermore this role appears to be evolutionarily conserved as a mammalian homologue of bir-1 could functionally complement bir-1 in C. elegans.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE