Accession Number:

ADA413707

Title:

Does c-Abl Play a Role in Brca1 Protein Complex Regulation?

Descriptive Note:

Annual rept. 1 Jul 2001-30 Jun 2002

Corporate Author:

TEMPLE UNIV PHILADELPHIA PA SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2002-07-01

Pagination or Media Count:

10.0

Abstract:

C-Abl and BRCA1 have certain overlaps that have led us to speculate of a functional relationship. In murine knockout studies each gene deficiencies affects spermatogenesis at the same stage of differentiation. In addition numerous nuclear proteins have been shown to interact both with c-Abl and BRCA1. In fact a recent publication points to a direct interaction resulting an association that can be disrupted by ionizing radiation.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE