Accession Number:

ADA413622

Title:

Translational Hyperactivity as a Target for Prostate Cancer

Descriptive Note:

Annual rept. 1 Jan 2002-31 Dec 2002

Corporate Author:

EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC

Personal Author(s):

Report Date:

2003-01-01

Pagination or Media Count:

115.0

Abstract:

This research project strives to advance our understanding of how cell signaling pathways mediated by the protein kinase C PKC gene family contribute to the translational hyperactivity that accompanies the unrestrained cell cycle reentry and unlimited replicative potential of prostate cancer cells Experiments designed to address these basic questions are intended to determine the mechanisms regulating the expression of PKC isozymes throughout the progression of prostate cancer and the metabolic consequences of enhanced expression for PKCepsilon PKCs Molecular and biochemical approaches are being employed to specifically determine how PKCs activity influences reactivation of the translational repressor protein retinoblastoma Rb, and thereby global protein synthesis, upon entry into the G1 phase of the cell cycle.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE