Translational Hyperactivity as a Target for Prostate Cancer
Annual rept. 1 Jan 2002-31 Dec 2002
EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC
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This research project strives to advance our understanding of how cell signaling pathways mediated by the protein kinase C PKC gene family contribute to the translational hyperactivity that accompanies the unrestrained cell cycle reentry and unlimited replicative potential of prostate cancer cells Experiments designed to address these basic questions are intended to determine the mechanisms regulating the expression of PKC isozymes throughout the progression of prostate cancer and the metabolic consequences of enhanced expression for PKCepsilon PKCs Molecular and biochemical approaches are being employed to specifically determine how PKCs activity influences reactivation of the translational repressor protein retinoblastoma Rb, and thereby global protein synthesis, upon entry into the G1 phase of the cell cycle.
- Anatomy and Physiology
- Medicine and Medical Research