Regulatable Gene Therapy for Prostate Cancer
Annual summary rept. 3 Dec 2001-2 Dec 2002
BAYLOR COLL OF MEDICINE HOUSTON TX
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Regulable gene therapy represents a new strategy to control and amplify efficacy of therapeutic gene. By the research efforts during this first period, two new regulators for inducible therapeutic gene expression have been generated, and an adenoviral construct of endostatin and its help-dependent adenovirus have been generated and tested in cell cultures, matrigel assays and two mouse tumor models. Although endostatin in the current system appeared rather weak to block tumor growth, the regulatory system for endostatin expression was proved to be highly effective for the pre-clinical study of the prostate cancer gene therapy. These stage results will facilitate the next period of functional studies on other candidate therapeutic genes suitable for prostate cancer therapy.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research