Accession Number:

ADA413563

Title:

Design and Synthesis of New Prostate Cancer Chemotherapeutic Agents

Descriptive Note:

Final rept. 1 Sep 1998-28 Feb 2001

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA

Personal Author(s):

Report Date:

2001-03-01

Pagination or Media Count:

30.0

Abstract:

This proposal is directed towards the development of new chemotherapeutic agents based on the mechanism of action of TaxolTM. The recent discovery of two other natural products, epothilone, and eleutherobin, which operate by the same unique mechanism of action as TaxolTM, i.e., microtubule stabilization, provides a unique opportunity for a collaborative approach to the elucidation of the pharmacophore common to these structurally dissimilar substances, using a combination of synthetic and computational studies. Such an advance could lead to the development of a novel family of prostate cancer chemotherapeutics

Subject Categories:

  • Medicine and Medical Research
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE