Accession Number:

ADA413477

Title:

Mortality and Morbidity Avoidance/Reduction of Respiratory Sickness Immediately Following Exposure to Bioweaponized Microbial Pathogens

Descriptive Note:

Final progress rept. 1 Mar 2001-31 Mar 2002

Corporate Author:

CASE WESTERN RESERVE UNIV CLEVELAND OH

Personal Author(s):

Report Date:

2002-06-26

Pagination or Media Count:

20.0

Abstract:

This proposal seek to develop 1 an effective broad-range formulation cocktail for pulmonary tract delivery as a countermeasure to inhaled microbial pathogens. The formulation will be polyvalent in both targeting and mechanism of action to enhance potency against multiple organisms and to prevent bioengineering to resist the formulation. 2 Bivalent components of the cocktail will be constructed by coupling targeting molecules to a variety of enzymes active against bacterial cell walls. Targeting compounds include, but are not limited to, unique inhibitors of a ubiquitous bacterial transport system important for virulence recently developed by the investigators. 3 The formulated cocktail will be compatible with self-administration upon exposure location prior to or after actual or suspected inhalation of pathogens. Chemical formulation of the cocktail will be compatible with current delivery vehicles such that the countermeasure could be deployed soon after demonstration of efficacy and approval of the formulation by the necessary regulatory agencies. Threat organisms treatable by the proposed novel unconventional countermeasure include, but are not limited to spores and vegetative cells of Bacillus anthracis, Clostridium spp., fungal lung pathogens in general and cells of Yersinia pestis, Francisella tularensis, Brucella suis, Salmonella typhi and related bacterial species.

Subject Categories:

  • Medicine and Medical Research
  • Microbiology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE