Understanding the Role of Replication Protein A and RAD52 in Breast Cancer
Annual rept. 25 Sep 2001-24 Sep 2002
TOLEDO UNIV OH
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This research focuses on structural studies of human replication protein A RPA and RAD52 in recombination-based repair of double-stranded DNA breaks. This DNA repair pathway has - been directly linked to breast cancer through BRCAl and BRCA2 protein-protein interactions. Also mutations in the ataxia telangiectasia AT gene are implicated in breast cancer and recently AT kinase was shown to phosphorylate the N-terminus of the 32 kDa subunit of RPA. The goals of the Borgstahl laboratory are to understand the role of RPA phosphorylation and RPARAD52 protein-protein interactions in DNA repair. The ultimate goal of this research is to provide an understanding of this process at the atomic level.
- Medicine and Medical Research