Accession Number:

ADA413412

Title:

Understanding the Role of Replication Protein A and RAD52 in Breast Cancer

Descriptive Note:

Annual rept. 25 Sep 2001-24 Sep 2002

Corporate Author:

TOLEDO UNIV OH

Personal Author(s):

Report Date:

2002-10-01

Pagination or Media Count:

30.0

Abstract:

This research focuses on structural studies of human replication protein A RPA and RAD52 in recombination-based repair of double-stranded DNA breaks. This DNA repair pathway has - been directly linked to breast cancer through BRCAl and BRCA2 protein-protein interactions. Also mutations in the ataxia telangiectasia AT gene are implicated in breast cancer and recently AT kinase was shown to phosphorylate the N-terminus of the 32 kDa subunit of RPA. The goals of the Borgstahl laboratory are to understand the role of RPA phosphorylation and RPARAD52 protein-protein interactions in DNA repair. The ultimate goal of this research is to provide an understanding of this process at the atomic level.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE