Breast Cancer Susceptibility and DNA Damage/Repair
Annual rept. 1 Jun 2001-31 May 2002
NEW YORK UNIV NY SCHOOL OF MEDICINE
Pagination or Media Count:
The study is based on breast cancer cases and matched controls from a cohort of women New York University Womens Health Study-NYUWHS who have been followed up for 7-13 years since they donated a blood sample and completed a health, lifestyle and dietary questionnaire to determine the incidence of breast cancer The original proposal was to genotype 6 polymorphisms in the genetic pathways for DNA repair or protection against DNA damage in 200 cases and 200 matched controls We expanded the study to 300 cases and 300 controls. For about 40 of subjects we had blood clots or cell aggregates left after separating out the serum from which to extract DNA, but for the remainder we had to extract it from the serum. There was abundant DNA in the clots and cell aggregates but much less in the serum.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research