Osteocalcin Promoter-Mediated Expression of Therapeutic Genes in Localized and Metastatic Human Prostate Cancer
Final rept. 1 Aug 1998-14 Oct 2002
INDIANA UNIV INDIANAPOLIS
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Osteocalcin OC expresses in both normal and cancerous prostate epithelial cells and prostate cancer metastasis to the bone and lymph node. The goal of this research is to develop a novel therapeutic agents based on osteocalcin promoter for the treatment of prostate cancer, particularly bone metastasis. Three therapeutic agents were proposed for testing thymidine kinase TK, cytosine deaminase CD, and Diphtheria toxin interleukin 13 fusion toxin DT-IL13. Recombinant adenovirus, Ad-OC-TK, carrying TK under the control of mouse OC promoter, with prodrug, has therapeutic efficacy on hormone refractory prostate cancers in animal models and had no toxic side effects in our formal toxicology study.
- Genetic Engineering and Molecular Biology
- Medicine and Medical Research