Mechanisms and Treatment of Progressive Damage After Traumatic Brain Injury
Annual rept. 1 Feb 2002-31 Jan 2003
MIAMI UNIV FL SCHOOL OF MEDICINE
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The purpose of this contract is to characterize progressive atrophy associated with long- term behavioral changes after traumatic brain injury TBI in the rat. In addition, mechanisms that contribute to this progressive atrophy will be studied in order to determine what appropriate treatment strategies can be designed to target these mechanisms. These studies utilize an established model of TBI that mimics many pathological and behavioral components of human head injury. Due to the chronic outcome measurements of the studies proposed, they are still ongoing. Therefore, no findings from these experiments can be reported yet. However, the initial study on progressive atrophy after TBI has been published. This study demonstrated both gray and white matter atrophy in vulnerable structures following TBI.
- Anatomy and Physiology
- Medicine and Medical Research