Accession Number:

ADA413329

Title:

Mechanisms and Treatment of Progressive Damage After Traumatic Brain Injury

Descriptive Note:

Annual rept. 1 Feb 2002-31 Jan 2003

Corporate Author:

MIAMI UNIV FL SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

2003-02-01

Pagination or Media Count:

13.0

Abstract:

The purpose of this contract is to characterize progressive atrophy associated with long- term behavioral changes after traumatic brain injury TBI in the rat. In addition, mechanisms that contribute to this progressive atrophy will be studied in order to determine what appropriate treatment strategies can be designed to target these mechanisms. These studies utilize an established model of TBI that mimics many pathological and behavioral components of human head injury. Due to the chronic outcome measurements of the studies proposed, they are still ongoing. Therefore, no findings from these experiments can be reported yet. However, the initial study on progressive atrophy after TBI has been published. This study demonstrated both gray and white matter atrophy in vulnerable structures following TBI.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE