Accession Number:

ADA413325

Title:

Progesterone Receptor Isoform Influence on Human Breast Tumor Growth and Hormone Treatment

Descriptive Note:

Final rept. 1 Jun 2001-31 Dec 2002

Corporate Author:

COLORADO UNIV AT FITZSIMMONS AURORA HEALTH SCIENCES CENTER

Personal Author(s):

Report Date:

2003-01-01

Pagination or Media Count:

30.0

Abstract:

Many postmenopausal women receive progestins in conjunction with estrogens as part of hormone replacement therapy. These women have a slightly higher risk of developing breast cancer than those receiving estrogen alone Progesterone mediates its affects through two known forms of the progesterone receptor, PR-A and PR-B. We aim to study how progesterone, via either PR-A or PR-B, influences estrogen-stimulated tumor formation and growth.

Subject Categories:

  • Biochemistry
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE