Accession Number:

ADA413324

Title:

Human Prostate Cancer in a Tissue Recombination Model

Descriptive Note:

Annual summary rept. 16 Apr 2001-15 Nov 2002

Corporate Author:

VANDERBILT UNIV MEDICAL CENTER ATLANTA GA

Personal Author(s):

Report Date:

2002-12-01

Pagination or Media Count:

12.0

Abstract:

In vivo models based on human epithelial cells hPrE will provide powerful tools with which to investigate cancer initiation and progression. Tissue recombinations TR composed of hPrE and rat urogenital sinus mesenchyme rUGM grafted beneath the renal capsule of immunocompromised rat hosts recapitulate many key events in prostatic development and adult function. The stable integration of known or putative oncogenes into the hPrE component of such TRs is a powerful tool with which to study the effects of these genesin vivo.

Subject Categories:

  • Anatomy and Physiology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE