Accession Number:

ADA413316

Title:

Fibrosis of the Breast Skin After Irradiation is Reversible and Preventable by Exogenous Decorin

Descriptive Note:

Annual rept. 1 Jul 2001-30 Jun 2002

Corporate Author:

ROCHESTER UNIV NY

Personal Author(s):

Report Date:

2002-07-01

Pagination or Media Count:

16.0

Abstract:

Cutaneous fibrosis after breast cancer radiotherapy is unavoidable, progressive, and irreversible. Currently there is no satisfactory, preventive therapy to ameliorate this process. Overexpression of fibrogenic cytokine TGF beta has been associated with soft tissue fibrosis, and reduction of its production or activation can ameliorate radiation induced normal tissue toxicity. Decorin is a small, leucine-rich proteoglycan, and is thought to be a natural inhibitor of TCF beta. In this study, we investigated whether decorin can reduce or prevent radiation induced acute and chronic damage to cutaneous tissue in mouse model. We showed 1 Inflammatory changes of the papillary dermis in several mouse strains occurred within two weeks of irradiation.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE