Role of TGF-1B1-Mediated Down Regulation of NF-kB/Rel Activity During Growth Arrest of Breast Cancer Cells
Annual summary 1 May 1998-31 Oct 2002
BOSTON UNIV MA
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NF-kBRel is a family of transcription factors, which are expressed in all cells however, in most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific inhibitory proteins, termed IKBs We have recently shown that NF-kBRel factors are aberrantly activated in breast cancer, and function to promote tumor cell survival Specifically, mammary tumors induced upon carcinogen treatment of Sprague-Dawley S-D rats, human breast tumor cell lines, and primary human breast tumor tissue samples were found to constitutively express high levels of nuclear NF-kBRel, whereas normal rat mammary glands and untransformed breast epithelial cells contained the expected low basal levels.
- Medicine and Medical Research