Accession Number:

ADA413313

Title:

Role of TGF-1B1-Mediated Down Regulation of NF-kB/Rel Activity During Growth Arrest of Breast Cancer Cells

Descriptive Note:

Annual summary 1 May 1998-31 Oct 2002

Corporate Author:

BOSTON UNIV MA

Personal Author(s):

Report Date:

2002-11-01

Pagination or Media Count:

31.0

Abstract:

NF-kBRel is a family of transcription factors, which are expressed in all cells however, in most non-B cells, they are sequestered in the cytoplasm in inactive complexes with specific inhibitory proteins, termed IKBs We have recently shown that NF-kBRel factors are aberrantly activated in breast cancer, and function to promote tumor cell survival Specifically, mammary tumors induced upon carcinogen treatment of Sprague-Dawley S-D rats, human breast tumor cell lines, and primary human breast tumor tissue samples were found to constitutively express high levels of nuclear NF-kBRel, whereas normal rat mammary glands and untransformed breast epithelial cells contained the expected low basal levels.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE