Accession Number:

ADA413308

Title:

The Molecular Basis of the Response to Radiation

Descriptive Note:

Final rept. 1 Jul 1997-30 Jun 2002

Corporate Author:

BAYLOR COLL OF MEDICINE HOUSTON TX

Personal Author(s):

Report Date:

2002-07-01

Pagination or Media Count:

59.0

Abstract:

This four year Career Development Award with a one year no cost extension has been completed We have made progress towards all three Technical Objectives. Reagents to complete genetic screens were developed in year 1 However, we encountered scientific problems isolating novel cDNAs encoding human homologs of yeast DNA damage response genes RAD9 and DUN1 during year 2 and year 3. In contrast, two hybrid screens resulted in the isolation of human homologs of RAD18 and RAD21 and the focus over years 3, 4 and 5 has been the characterization of the human Rad21 protein in mammalian cells and its degradation in response to DNA damage.

Subject Categories:

  • Biochemistry
  • Genetic Engineering and Molecular Biology
  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE